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Syzygy March 2018 09-03-2018

In this edition of Syzygy:

  • M. genitalium detection and resistance testing - an article by Dr Jenny Robson, pathologist-in-charge, Department of Microbiology and Infectious Diseases
  • Changes to services for Easter 2018
  • Special request forms for skin allergy and therapeutic venesection
  • Insights into Cervical Screening Testing: CST clinical audit
Holter Monitor 14-03-2018
Patient Brochures

Holter Monitor: Information for patients

Whenever your heart beats the process is started by an electrical impulse in the top right hand corner of your heart. This impulse then travels in a diagonal direction to the bottom left hand corner of your heart and spreads to various other parts of the heart along the way causing the muscles of the heart to contract and make the heart beat.

Histamine Diet 13-04-2018
Patient Test Collection Instructions

A histamine-free diet must be maintained for the 24 hours prior to and during collection of 24 hour urine.

Semen Collection 19-04-2018
Patient Test Collection Instructions

Step by Step collection instructions.

Skin Cancer 20-04-2018
Patient Brochures

A skin cancer is the uncontrolled growth of abnormal cells in the skin. These abnormal cells usually arise from prolonged exposure to sunlight, which can alter the genetic makeup of the cells, causing the cells to mutate. These mutated cells then continue to replicate and a skin cancer can form.

Biotin interference 23-04-2018
Doctor Bulletins

High dose biotin intake may cause interference with laboratory test results.

The potential for both endogenous and exogenous substances to produce artefactual changes in laboratory results is well recognised. Causes of analytical artefact include haemolysis, lipaemia, paraproteins, heterophile antibodies and ingested agents such as biotin (vitamin B7).

It is important to note that biotin has noeffect upon commonly requested biochemistry tests, such as electrolytes, urea, creatinine and liver function tests. For some immunoassay-based methods, however, biotin has always been a potential cause of interference with tests that use biotin-streptavidin in their matrix. Although these assays are not affected by ingestion of low-dose biotin, taking high-dose biotin prior to blood collection may cause significant interference with test results.

Syzygy May 2018 16-05-2018

In this edition of Syzygy:

  • New prenatal tests from Sonic Genetics: Preconception carrier screening panel and Extended Harmony® with 22q11.2 deletion
  • Biotin interference on laboratory assays
  • Introducing Dr Margreth van Aartsen, dermatopathologist
Critical Result Values 21-05-2018
Doctor Bulletins

Critical values are those results that may indicate a life threatening medical condition and require immediate notification to the referring doctor (irrespective of whether the pathology request was marked urgent).

If a result outside the critical limits is obtained, a scientist or pathologist will make every attempt to contact the referring doctor.

BRCA1 and BRCA2 testing - Medicare update for doctors 25-05-2018
Doctor Bulletins

Testing of the genes responsible for familial breast or ovarian cancer is now rebated. Medicare rebates will improve access to genetic testing and it is important to understand the new criteria in order to best support your patients.

Key points:

  • BRCA1 and BRCA2 are the genes most commonly implicated, but familial mutations in other genes such as STK11, PTEN, CDH1, PALB2, and TP53 can also cause familial breast cancer. Mutations in any of these genes can also cause cancers other than breast and ovarian cancers in both men and women.
  • There are a number of settings in which rebated testing of BRCA and other genes responsible for familial breast and ovarian cancer is available:

- Testing an individual with advanced ovarian cancer

- Testing an individual with breast or ovarian cancer and relevant family history

- Testing an individual who does not have cancer but has family history

  • Specific clinical requirements apply for Medicare eligibility.
  • Medicare stipulates that requests for such testing can only be made by a medical specialist or consultant physician. General practitioners cannot order rebated BRCA gene testing.
  • Testing can be performed for patients who do not meet the Medicare requirements, however BRCA gene testing will be privately billed. Sonic Genetics still requires that privately billed tests are requested by a medical specialist or consultant physician and that pre-test counselling with written consent has been completed.
Perfluorinated chemical testing - PFAS - PFOS 01-06-2018
Doctor Bulletins

Sullivan Nicolaides Pathology is now testing for the perfluoroalkyl substances including perfluorooctane sulphonate (PFOS) and perfluorooctanoic acid (PFOA).

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